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Big News for Cure Alzheimer’s

n-ALZHEIMERS-large570Anyone who knows anyone effected by Alzheimers can appreciate the breakthrough research that was announced this week by the journal Nature. For my family, this is BIG news. My grandparents have been very active in Cure Alzheimer’s and anytime one is dedicated personally and financially in a cause, it’s exciting to see all the hard work pay off. At Just Like Family Home Care, we are asked to take care of many patients who have Alzheimers. While all illness is challenging to care for, Alzheimer’s is one of the hardest to watch. I’m am excited about this research and I hope it continues to fuel new findings that will ultimately lead to a cure.

See the full article below:

For the first time, and to the astonishment of many of their colleagues, researchers created what they call Alzheimer’s in a Dish — a petri dish with human brain cells that develop the telltale structures of Alzheimer’s disease.

So begins a new story in the New York Times by science reporter Gina Kolata announcing breakthrough research just published by the journal Nature.

The research, conducted by Dr. Rudy Tanzi and Massachusetts General Hospital (MGH) colleagues Drs. Doo Yeon KimSe Hoon Choi and Dora Kovacs and funded by Cure Alzheimer’s Fund (CAF), demonstrates for the first time precisely how the protein Abeta (the main component of plaques) stimulates the creation of tau “tangles.” Further, the researchers identified a key enzyme in this process.

“It is a giant step forward for the field,” Duke Univeristy’s Dr. P. Murali Doraiswamy told the Times. “It could dramatically accelerate testing of new drug candidates.”

The Tanzi breakthrough simultaneously boosts Alzheimer’s research in three vital ways:

First, it gives reseachers final confirmation of the “amyloid hypothesis,” a long-disputed theory about the earliest stages of the disease.

Second, it provides a promising new therapeutic target. “Here we show for the first time that Abeta deposition by human neurons is sufficient to lead to tangles,” said Tanzi, director of the Genetics and Aging Research Unit at MGH and chairman of CAF’s Research Consortium. “If you block the amyloid deposition, you block tangles from forming downstream.”

Finally, the experiment was conducted with an innovative and powerful new tool: use of human Alzheimer’s neurons derived from non-embryonic stem cells grown in a petri dish. “We call this system Alzheimer’s-in-a-Dish,” Tanzi said. “This is the first time anyone has successfully recapitulated amyloid and tau pathology in a single human neural cell culture. It creates a near-ideal lab model of the disease that will help us dramatically accelerate drug testing.”

Jeffrey L. Morby, Chairman of Cure Alzheimer’s Fund, welcomed the research breakthrough and the high-level recognition. “We’re so gratified that Nature, one of the world’s most prestigious science journals, and The New York Times, the newspaper of record, have both recognized the profound importance of this research. But we won’t rest on these laurels. We are already leveraging these exciting discoveries into even more aggressive research. We are determined to stop this dreadful disease as soon as humanly possible.”

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The New York Times story can be found here. Please note, it is Times policy not to mention the names of funders when covering scientific studies.

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Want to learn more about Dr. Tanzi’s research? Watch his presentation during our symposium live stream on Wednesday, October 15.


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SAVE THE DATE: Celebrity Bartending to Celebrate Senior Citizens

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Noodles Italian Café and Sushi Bar, a locally owned restaurant at Mission Plaza in Naples, will host a fundraiser to help support Southwest Florida Seniors in need on Wednesday, May 14, from 5:30 p.m. to 7:30 p.m.

Just Like Family Home Care, a family-owned home care company servicing seven Southwest Florida counties, is celebrating Senior Citizens Month this May and partnering with Noodles to present a celebrity bartending night. The event is designed to raise awareness of the growing need to help seniors, especially during the summer months.

“Summer is an extremely slow time of year in terms of donations and many of our local non-profits are very low on supplies,” says Nassberg. “People are so generous around the holidays, but our hope is that this Senior Drive will spark giving at a time when it is most needed.”

The cost for one ticket will be $20, and will include a variety of foods, plus one free drink ticket. Tickets for the fundraiser may be purchased at the door. $10 from each ticket and tips raised by the celebrity bartenders will be split between St. Matthews House and Goodlette Arms.

Guests are also asked to bring one new item that can be donated to Just Like Family’s Senior Collection Drive. Throughout the month of May, JLF is collecting items for seniors. Suggested donations include socks, shampoo, pajamas, games, glasses, sweaters, blankets, stamps, wheelchairs, walkers, medical supplies and personal hygiene items.

In June, the donations will be distributed to St. Matthews House and Goodlette Arms, a low income, housing apartment for seniors subsidized by the federal governments HUD.

For more information, contact Just Like Family Home Care at 239.431.6661 or visit justlikefamilyhomecare.com.